As Jim explores the empty streets of London, he realizes that the virus has turned most of the population into aggressive, bloodthirsty zombies. Jim eventually meets other survivors, including Selena (Naomie Harris), Frank (Brendan Gleeson), and Hannah (Megan Burns). Together, they try to navigate the desolate landscape, seeking refuge and safety.
The survivors face not only the threat of the infected but also the dangers posed by other uninfected humans who have become desperate and violent in their struggle for survival. What sets 28 Days Later apart from other zombie films is its use of fast-moving, enraged, infected individuals instead of traditional slow-moving creatures.